This paper applies single-cell RNA sequencing (scRNA-seq) to dissect cellular heterogeneity in mouse models of Alzheimer’s disease.
Key points:
- Dataset: scRNA-seq from hippocampus region at different stages of disease progression.
- Findings:
- Identification of 5 major microglia subtypes.
- Disease-associated microglia (DAM) emerge early and expand with time.
- Conclusion: Dynamic microglia states correlate with amyloid burden and neuroinflammation.
This study underscores the potential of single-cell technologies to uncover immune dynamics in neurodegenerative disorders.